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Scavenger receptor class B member 1

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mammalian protein found in Homo sapiens

Risorse esterne

identificativo Freebase
/m/03d01c0
Ensembl protein ID
ENSP00000261693[1]
ENSP00000343795[2]
ENSP00000414979[3]
ENSP00000442862[4]
ENSP00000443454[5]
ENSP00000444851[6]
identificativo Microsoft Academic
2779328381
identificativo UniProt
Q8WTV0[7]
Transporter Classification Database ID
9.B.39.1.3[8][9]
identificativo RefSeq di una proteina
NP_001076428[10]
NP_005496[10]
NP_001354910[10]
NP_001354911[10]
NP_001354912[10]
NP_001354913[10]
NP_001354914[10]
NP_001354915[10]
NP_001354916[10]
NP_001354917[10]
NP_001354918[10]

no tipo 'e

proteina[7]

parte 'e

CD36/scavenger receptor class B member 1[11]
Putative uncharacterized transport proteins[12]

trovato nella tassonomia de

Homo sapiens[7]

codificato da

SCARB1[7]

funzione molecolare

apolipoprotein binding[13][14]

metodo di determinazione: IEA, IPI

protein homodimerization activity[14]

metodo di determinazione: IEA

virus receptor activity[15]

metodo di determinazione: IEA

transporter activity[16]

metodo di determinazione: TAS

high-density lipoprotein particle receptor activity[17][18]

metodo di determinazione: IDA, IMP

phosphatidylserine binding[19][14]

metodo di determinazione: ISS, IEA

apolipoprotein A-I binding[13][20]

metodo di determinazione: IPI

lipopolysaccharide binding[21]

metodo di determinazione: IDA

low-density lipoprotein particle binding[18]

metodo di determinazione: IDA

1-phosphatidylinositol binding[22]

metodo di determinazione: TAS

legame dei farmaci alle proteine plasmatiche[23][24][25]

metodo di determinazione: IPI

high-density lipoprotein particle binding[14]

metodo di determinazione: IEA

lipopolysaccharide immune receptor activity[21]

metodo di determinazione: IDA

amyloid-beta binding[14]

metodo di determinazione: IEA

scavenger receptor activity[26]

metodo di determinazione: TAS

componente cellulare

citoplasma[14]

metodo di determinazione: IEA

integral component of membrane[15][14]

metodo di determinazione: IEA

endocytic vesicle membrane[27]

metodo di determinazione: TAS

intracellular membrane-bounded organelle[28]

metodo di determinazione: IDA

membrana[15][29]

metodo di determinazione: IEA

membrana cellulare[27][15][18]

metodo di determinazione: IDA, TAS, IEA

integral component of plasma membrane[14]

metodo di determinazione: IEA

cell surface[30][14]

metodo di determinazione: ISS, IEA

lysosomal membrane[31]

metodo di determinazione: IDA

Caveole[32][15][14]

metodo di determinazione: TAS, IEA

extracellular exosome[33]

metodo di determinazione: IDA

microvillus membrane[14]

metodo di determinazione: IEA

lysosomal membrane[34]

metodo di determinazione: HDA

extracellular exosome[35]

metodo di determinazione: HDA

processo biologico

cholesterol import[36][37][17][14]

metodo di determinazione: ISS, IEA, IMP

positive regulation of triglyceride biosynthetic process[19][14]

metodo di determinazione: ISS, IEA

regulation of phosphatidylcholine catabolic process[19][14]

metodo di determinazione: ISS, IEA

recognition of apoptotic cell[14][18]

metodo di determinazione: IDA, IEA

lipid transport[14]

metodo di determinazione: IEA

low-density lipoprotein particle clearance[19][14]

metodo di determinazione: ISS, IEA

blood vessel endothelial cell migration[14]

metodo di determinazione: IEA

positive regulation of cholesterol storage[18]

metodo di determinazione: IDA

phospholipid transport[19][14]

metodo di determinazione: ISS, IEA

cholesterol transport[14]

metodo di determinazione: IEA

guarigione delle ferite[38]

metodo di determinazione: TAS

cholesterol catabolic process[14]

metodo di determinazione: IEA

receptor-mediated endocytosis[27]

metodo di determinazione: TAS

high-density lipoprotein particle remodeling[19][14]

metodo di determinazione: ISS, IEA

positive regulation of endothelial cell migration[38]

metodo di determinazione: TAS

androgen biosynthetic process[14]

metodo di determinazione: IEA

vitamin transmembrane transport[17]

metodo di determinazione: IMP

positive regulation of nitric-oxide synthase activity[39]

metodo di determinazione: IDA

endothelial cell proliferation[14]

metodo di determinazione: IEA

lipopolysaccharide transport[21]

metodo di determinazione: IDA

cholesterol efflux[36][40][14]

metodo di determinazione: ISS, IEA, IMP

phagocytosis, recognition[14]

metodo di determinazione: IEA

viral entry into host cell[41]

metodo di determinazione: IEA

intestinal absorption[14]

metodo di determinazione: IEA

cholesterol homeostasis[19][14]

metodo di determinazione: ISS, IEA

regulation of phagocytosis[14][42]

metodo di determinazione: IC, IEA

adhesion of symbiont to host[43]

metodo di determinazione: IMP

viral process[15]

metodo di determinazione: IEA

detection of lipopolysaccharide[21]

metodo di determinazione: IDA

triglyceride homeostasis[19][14]

metodo di determinazione: ISS, IEA

trasporto inverso del colesterolo[44][14]

metodo di determinazione: IEP, IEA

lipopolysaccharide-mediated signaling pathway[41]

metodo di determinazione: IEA

high-density lipoprotein particle clearance[27][18]

metodo di determinazione: IDA, TAS

interagisce fisicamente con

Viroporin 3a[45]

metodo di determinazione: Affinity Capture-MS

Riferimento

  1. ↑ Ensembl Release 99, ENSP00000261693
  2. ↑ Ensembl Release 99, ENSP00000343795
  3. ↑ Ensembl Release 99, ENSP00000414979
  4. ↑ Ensembl Release 99, ENSP00000442862
  5. ↑ Ensembl Release 99, ENSP00000443454
  6. ↑ Ensembl Release 99, ENSP00000444851
  7. ↑ 7,0 7,1 7,2 7,3 UniProt, 13 Nuv 2019, Q8WTV0
  8. ↑ Classificazione TC, 13 Màr 2020
  9. ↑ Classificazione TC, 29 Abb 2020
  10. ↑ 10,00 10,01 10,02 10,03 10,04 10,05 10,06 10,07 10,08 10,09 10,10 NCBI Gene, 30 Maj 2020, 949
  11. ↑ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/Q8WTV0
  12. ↑ 9.B.39.1.3, 2 ott 2019, hierarchical database ID heuristic
  13. ↑ 13,0 13,1 British Heart Foundation, 8 Abb 2019, Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  14. ↑ 14,00 14,01 14,02 14,03 14,04 14,05 14,06 14,07 14,08 14,09 14,10 14,11 14,12 14,13 14,14 14,15 14,16 14,17 14,18 14,19 14,20 14,21 14,22 14,23 14,24 14,25 14,26 14,27 14,28 14,29 14,30 Ensembl, 8 Abb 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  15. ↑ 15,0 15,1 15,2 15,3 15,4 15,5 GOA, 8 Abb 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, IEA
  16. ↑ Proteome Inc., 8 Abb 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  17. ↑ 17,0 17,1 17,2 AgBase, 8 Abb 2019, Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  18. ↑ 18,0 18,1 18,2 18,3 18,4 18,5 British Heart Foundation, 8 Abb 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  19. ↑ 19,0 19,1 19,2 19,3 19,4 19,5 19,6 19,7 British Heart Foundation, 8 Abb 2019, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  20. ↑ British Heart Foundation, 8 Abb 2019, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  21. ↑ 21,0 21,1 21,2 21,3 British Heart Foundation, 8 Abb 2019, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  22. ↑ British Heart Foundation, 8 Abb 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  23. ↑ IntAct protein interaction database, 8 Abb 2019, A proteome-scale map of the human interactome network, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  24. ↑ IntAct protein interaction database, 8 Abb 2019, The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  25. ↑ AgBase, 8 Abb 2019, The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  26. ↑ ARUK-UCL, 8 Abb 2019, Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  27. ↑ 27,0 27,1 27,2 27,3 Reactome, 8 Abb 2019, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  28. ↑ Human Protein Atlas, 8 Abb 2019, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  29. ↑ InterPro, 8 Abb 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  30. ↑ British Heart Foundation, 8 Abb 2019, Scavenger receptor SR-BI in macrophage lipid metabolism, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  31. ↑ Integral and associated lysosomal membrane proteins, GOA, 9 Maj 2017, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0, IDA
  32. ↑ British Heart Foundation, 8 Abb 2019, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  33. ↑ MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, 9 Maj 2017, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0, IDA
  34. ↑ Integral and associated lysosomal membrane proteins, GOA, 8 Abb 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, HDA
  35. ↑ MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, 8 Abb 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, HDA
  36. ↑ 36,0 36,1 British Heart Foundation, 8 Abb 2019, Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  37. ↑ Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease, GOA, 8 Abb 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, IMP
  38. ↑ 38,0 38,1 British Heart Foundation, 8 Abb 2019, Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  39. ↑ British Heart Foundation, 8 Abb 2019, High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  40. ↑ AgBase, 8 Abb 2019, ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  41. ↑ 41,0 41,1 Gene Ontology Consortium, 8 Abb 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  42. ↑ British Heart Foundation, 8 Abb 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  43. ↑ British Heart Foundation, 9 Maj 2017, Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor, GOA, IMP, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0
  44. ↑ British Heart Foundation, 8 Abb 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, IEP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  45. ↑ BioGRID, A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing, https://thebiogrid.org/news/227, 19 Abb 2020
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